The only time I’ve heard of serotonin syndrome being a real (common) risk is with MAOIs and alcohol…
Shrooms/SSRIs causing it is not something I’ve ever been able to find information about. Every time I try to dig something up, because I am pretty careful about mixing drugs, the vague consensus (that is, in sources that aren’t making blanket statements about recreational drugs in general being bad because drugs are bad) is it’s probably fine, maybe it lessens the trip altogether, maybe it lessens the negative side effects of the trip, we just need to look into it more. Serotonin syndrome is a conspicuous thing to not mention if that’s a risk with any significant merit to it.
It’s certainly an emerging field due to psilocybin’s place on the drug schedule preventing any very extensive research. It seems to me like that claim is based mostly on conjecture that because they both can increase presence of serotonin, that has potential to become a risky situation with SSRIs. Mind you, however, that the exact mechanisms of this are not fully understood by science and so aren’t very good bases to draw sweeping conclusions from without research or data.
I’m both an SNRI user (strattera) and occasional psychonaut (not more than once a month, if I had to give an average for the year). I’ve never had anything but positive experiences with mushrooms and haven’t noticed any difference on vs off my SNRI.
Had a bad trip on acid once but that was more down to hubris than anything else. I wasn’t even on the SNRI back then.
This is of course anecdotal so absolutely take in all the information and make your own decisions for your body. Just thought I’d share what I know.
(Sorry for all the edits, my longer comments tend to be living documents for their first 10 minutes of life or so, mostly for grammar fixes)
Yeah, the info I was speaking from was mostly from a concern for the seraronin syndrome, not from hard evidence because like you said, it’s an emerging area of study.
I did just see a study a few days ago, coincidentally, where the abstract said they found a 3 to 6 months period of time from last dose of an SSRI before it stopped interfering with shrooms trips.
Yeah, tolerance and dosing with shrooms is kinda tricky (as in there’s a trick to it, not that it’s really difficult) if you’re doing them with any regularity. I wouldn’t be surprised if it’s similar to that where you have to take quite a bit more to not only break the threshold to trip again but achieve the same level of trip, and your tolerance lessens with each day that passes.
I might be able to attest to that if I had been doing shrooms a little longer before I started strattera. Perhaps it’s harder to achieve higher level trips, now that I think about it. But this is new information to me so it’s something I’ll have to keep an eye on. I happened to take .3g last night and got a bit more bang for my buck than expected. I also forgot to take my strattera yesterday. Coincidence? Maybe, maybe not. Low level trips are still valuable though imo.
The only time I’ve heard of serotonin syndrome being a real (common) risk is with MAOIs and alcohol…
Shrooms/SSRIs causing it is not something I’ve ever been able to find information about. Every time I try to dig something up, because I am pretty careful about mixing drugs, the vague consensus (that is, in sources that aren’t making blanket statements about recreational drugs in general being bad because drugs are bad) is it’s probably fine, maybe it lessens the trip altogether, maybe it lessens the negative side effects of the trip, we just need to look into it more. Serotonin syndrome is a conspicuous thing to not mention if that’s a risk with any significant merit to it.
It’s certainly an emerging field due to psilocybin’s place on the drug schedule preventing any very extensive research. It seems to me like that claim is based mostly on conjecture that because they both can increase presence of serotonin, that has potential to become a risky situation with SSRIs. Mind you, however, that the exact mechanisms of this are not fully understood by science and so aren’t very good bases to draw sweeping conclusions from without research or data.
I’m both an SNRI user (strattera) and occasional psychonaut (not more than once a month, if I had to give an average for the year). I’ve never had anything but positive experiences with mushrooms and haven’t noticed any difference on vs off my SNRI.
Had a bad trip on acid once but that was more down to hubris than anything else. I wasn’t even on the SNRI back then.
This is of course anecdotal so absolutely take in all the information and make your own decisions for your body. Just thought I’d share what I know.
(Sorry for all the edits, my longer comments tend to be living documents for their first 10 minutes of life or so, mostly for grammar fixes)
Thank you for this post with information.
Yeah, the info I was speaking from was mostly from a concern for the seraronin syndrome, not from hard evidence because like you said, it’s an emerging area of study.
I did just see a study a few days ago, coincidentally, where the abstract said they found a 3 to 6 months period of time from last dose of an SSRI before it stopped interfering with shrooms trips.
Found it again: https://pubmed.ncbi.nlm.nih.gov/37291890/
Interested in your thoughts.
I haven’t delved too deep into this topic because everything I have read ranges from you won’t get anything from it to its actual dangerous for you.
Yeah, tolerance and dosing with shrooms is kinda tricky (as in there’s a trick to it, not that it’s really difficult) if you’re doing them with any regularity. I wouldn’t be surprised if it’s similar to that where you have to take quite a bit more to not only break the threshold to trip again but achieve the same level of trip, and your tolerance lessens with each day that passes.
I might be able to attest to that if I had been doing shrooms a little longer before I started strattera. Perhaps it’s harder to achieve higher level trips, now that I think about it. But this is new information to me so it’s something I’ll have to keep an eye on. I happened to take .3g last night and got a bit more bang for my buck than expected. I also forgot to take my strattera yesterday. Coincidence? Maybe, maybe not. Low level trips are still valuable though imo.