Personally I’ve watched the series every now and then, but not enough to know every single episode.
So frankly I was curious on what people thought was the most diabolical joke/ skit they’ve ever done. considering this series has tons of them, I’ll probably get a good chuckle from the best ones
Showing actual sexchange footage in Mr. Garrisons fancy new vagina.
Nelson Browns existence in Stanley’s cup.
The stemcell antics of a Kenny Dies.
Butters accountabillabuddy in Cartman ducks
That’s off the top of the head. There’s more