Gonna start calling myself a thinktank and writing transhumanist sci-fi seeseepee fan fiction

so what i don’t understand is how prions can be resisted

basically all prion diseases that we know of are not curable and have a 100% fatality rate

and whether the epidemiology of a prion disease is about who ingests/receives an incorrectly folded protein

well, it can depend on some things, like for example if there was a difference in how well your body worked without that certain protein being functional compared to another person who is less resilient when this particular protein doesn’t work well, it’s kind of the reason why the incubation period varies so widely, the build up and conversion from good proteins to misfolded ones isn’t instant and takes time, so until that build up gets to a level where it causes symptoms we just don’t know that the person has anything wrong with them

or about individuals with particularly… foldable? proteins getting a prion and developing an illness that others wouldn’t.

there’s variation between people of course, but no if a prion is a certain protein and you expose it to proteins of the same kind it makes them misfold, maybe certain people have a different variation of that protein that does the same job but is structured a little differently so it’s not as susceptible or at all even, but that’s speculation on my part, I haven’t read deeply into this particular topic, generally speaking research into prion disease is still very inadequate, it’s very rare, and is always fatal, so it’s kind of hard to do research on

i’m particularly confused because the immune system isn’t involved, is it?

yeah the immune system can’t really fight it typically, because the protein matches the ones that the body uses, there isn’t much to tip it off since the immune system doesn’t look at protein folding, it looks at what proteins, sugars, and other molecules something has, in fact, the immune system can actually help the prion disease move into the body and reduce the incubation period as was seen in this study on rats, https://sci-hub.se/https://doi.org/10.1006/clim.2000.4875

oh also, not every exposure would mean 100% getting infected, especially since the propagation of the misfolding isn’t instant and takes time, so if those proteins get disposed of and replaced before they can spread (as the body naturally does dismantle and rebuild lots of proteins) then you wouldn’t get infected

though keep in mind that these are rare diseases, that affect like 1-2 people per million worldwide every year, some of those cases are due to infection (acquired), some are due to genetic issues that are inherited, meaning the body itself makes misfolded proteins sometimes due to genes being coded with a bad mutation in the area that codes for that protein, and some are just sporadic, meaning one protein just decides to misfold because it got built slightly wrong cause that person is extremely unlucky and then it spreads

more reading here https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890484/

generally speaking, not something you wanna ever risk the chance of making more common

first of all, the game is alright, and second there isn’t actually any sex, it’s just a horror game with an extremely abusive manipulative sister/brother dynamic where there are a lot of fucked up things that happen like eating the neighbor, sacrificing souls to a demon, etc, near the end of the game there’s a choice you can make that is that the sister gets more serious about making sure her brother is only hers and that implies incest, for some reason people on twitter got really mad at the inclusion of incest as a topic when it’s very obviously not an endorsement but a bad theme like all of the others the game gets into

testing for prions, especially for ones that you don’t know of yet (which can develop at any time in any person due to the nature of prions, but that’s very very rare) is extremely difficult, when mad cow disease is detected in a cattle herd you cull the herd, it isn’t worth it, the risk is far too high, and prions cannot be removed through anti-biotics or any kind of treatment, the only way to destroy them is denaturation through burning

prions are misshapen proteins that ‘spread’ in that when they touch the normally shaped proteins of the same kind they can cause them to become misshapen in the same way too, and being misshapen means this protein can’t do its job, and when it’s job is keeping your brain working or doing other important biological functions, you can see where issues arise

someone who was healthy at the end of their life may have prions in their body that were dormant and did not show symptoms, the longer you live the more likely you are to have proteins become misshapen, most are harmless and wouldn’t spread anyway, and most people die without developing anything to do with prions because of just how unlikely it is to happen

but in the rare chance someone’s body produces a misfolded protein that is both infectious and affects an important biological function then that extremely small chance would be buried in the ground or incinerated the majority of the time, but if more people practiced cannibalism then that protein would have a field day as it spread to the first person and then through blood contact spread to others, because a lot of prion disease is slow acting and/or has a very long incubation period (multiple years)

so not practicing cannibalism makes it a lot less likely for an untreatable deadly prion disease to materialize

on discord on linux you can’t screenshare with desktop audio, I think this might be already fixed in newer electron versions (but discord is closed source and has not updated their electron in a long time)

Something something I hope for a future where I’ll face the wall for being a reactionary something something

For people frequently chanting about death to various things, y’all are surprisingly literal.

He thinks the death to america posts aren’t literal

‘Warak enab’ (ورق عنب) is how you say ‘grape leaves’ in arabic, so, that’s the same dish yeah, they’re stuffed with rice mainly

Even with the meaning of Semite=Jew

That’s still incredibly antisemitic, saying all jews are Zionists is just calling all jews supporters of genocide, apartheid, and ethnic cleansing, it’s untrue of course, being a Jew has nothing to do with supporting ethnic cleansing and the existence of the state of Israel

foolish of you to assume that Zionism isn’t inherently bigoted, and most liberals would also get themselves banned for bigotry or toxicity fairly quickly I suppose

this, propose giving half of germany to the jews

like the others said, generalizing over jews like that is at least a little antisemitic, there are a lot of jews that do recognize the genocide and are anti-zionist/anti-Israel, or at least are speaking out against current Israeli action even if they don’t recognize the rest of Israel’s crimes

so, zionists as a group do only care about the holocaust because it happened to their group. but this is not the case for all jews.

fan channels do put segments like this on youtube, his official channel doesn’t upload most of the things he streams, I found a video here uploaded by a fan https://www.youtube.com/watch?v=iXF5C2c0UYs

implying that displacement from Gaza wouldn’t be, I guess it’s better than nothing, they set a redline that they’ll hopefully follow up on if it comes to it

there’s more than the ones in the list?

I personally think it’s nice to see but as always each community isn’t a monolith, though I think generally like, it’s accepted to wear it to show solidarity.

we don’t like apartheid, and we don’t like ethnostates.

China disables persons’ federation

I’ve read too much lemmy drama, I somehow thought this was about China disabling federation with “persons” and was confused for a few moments

What are your recommendations for android apps that support org-mode?

I do use emacs extensively for programming mainly but I’ve recently been feeling the itch to actually make real organized notes so org-mode is a pretty natural choice for me, I’ve actually played with org before to write a small paper for uni (exporting to latex) and it was a nice experience

And another question, how do you organize your notes with a setup like this (syncthing and phone app)? And can you link from a note to another one? Do you just have all of your notes in a single directory or are they like organized into folders for topics?

https://youtu.be/XRpHIa-2XCE?si=tbYkRe19ewCKWgwn

This is a nice video I recently watched on the topic