I gave myself nerve damage due to poor bike fit, thankfully it healed. After that I did a full overhaul of my bike fit. Flipped my stem up and raised it a bit with spacers. Removed bar tape and brifters, adjusted bar angle to maintain neutral wrist position in the drops. Installed brifters and positioned them for neutral wrist position on the hoods. I got a saddle with a large cutout and positioned it slightly farther back and down to put less weight on my hands. After that I could ride centuries or more without nerve damage to my hands or my perineum.

I also shifted the cleats on my shoes as far towards my arch as they would go and adjusted my seat height accordingly. This puts less stress on calves and Achilles and gives your posterior chain more direct connection to the bike.