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Sinclair has suggested human trials could commence within next year. “This new discovery offers the potential to reverse aging with a single pill, with applications ranging from improving eyesight to effectively treating age-related diseases.” Other biologists skeptical.

  • zlatiah@kbin.social
    51·
    1 year ago

    Oh boy it’s my time to shine!

    I’m working in aging right now. Heard of Dr. David Sinclair since he was the corresponding author on a paper I was curious about… So this is what his lab is doing.

    Two important disclaimers:

    • Success in cellular research rarely translates to something viable in the clinic. A lot of chemicals don’t behave the same way in cells as in actual animals or humans. Heck, a good number of phase 2 drugs even fail, and these haven’t even made it into phase 1… so I wouldn’t be too optimistic about them.
    • The journal Aging is not the most prestigious journal especially for someone working at Harvard Medical School (HMS) to be honest. I’d be more excited if this was published in Nature Aging or Nature Communications or something. If this ever gets published in New England Journal of Medicine (a very prestigious journal only for clinical studies) then we have some news.

    The link between cell senescence and aging is something actively being studied tho.

    And, if anyone is curious about this topic: I’m also very actively following Dr. Vadim Gladyshev who is also from HMS and is working in aging, I believe he is doing some wet lab-biology on a similar area as well. Feels like his research is sometimes a bit ahead of his time but I think his work has great potential.