There are definitely “quirks”, even with a lot of the gold/platinum rated games on protondb. E.g. Titanfall 2, horrible crackling audio issues at times, even though it runs great otherwise. Firewatch, random choppy slowdowns, but rare. BattleBit, sometimes (not too often) 20 seconds of 20fps, then back to normal.
There are definitely “quirks”, even with a lot of the gold/platinum rated games on protondb. E.g. Titanfall 2, horrible crackling audio issues at times, even though it runs great otherwise. Firewatch, random choppy slowdowns, but rare. BattleBit, sometimes (not too often) 20 seconds of 20fps, then back to normal.