“In essence, DMT-induced ‘mystical’ experiences appear to manifest in the body as an unusual state of coactivation of cardiac sympathetic and parasympathetic activity,” Bonnelle said. “Not only was this paradoxical physiological state of peaceful activation strongly related to spiritual and insightful experiences, but it was also predictive of well-being improvement after the experience. Our results also suggest that practices that promote the cultivation of balance between the two branches of the autonomic nervous system may facilitate the occurrence of such a state.”