There are occasional forum posts with lab results by transwomen who suspect they may have an unstudied SHBG variation causing a preferential bond to the strong agonist E1 which some claim might generally result in a greater prevalence of the weaker agonist E2 being available to cell estrogen receptors. Some further speculate this claimed SHBG variation to be a possible causal mechanism for the three atypical sexual dimorphisms observed in the brains of transwomen.

Generally such folks say they see better results following a switch from pills to injections and orchiectomy. Please take all of this with a grain of salt. However, it could be good idea to ask your doctor about getting your E1 and E2 levels checked.

Why quit HRT? Those transwomen who came before us made due with far fewer options than we have today. A glass is not perfectly filled to just the right, perfect height or else unenjoyable!