Restriction enzymes cut at specific sequences, and although there are lots of variations, this limits where the new material can be inserted. CRISPR can match an arbitrary sequence, so there is much more control over where changes are made.
Yes, although it’s not completely arbitrary as you need a PAM sequence to be present right where you want to cut the DNA. It’s quite small though so chances are, you’ll find one in a convenient location
Restriction enzymes cut at specific sequences, and although there are lots of variations, this limits where the new material can be inserted. CRISPR can match an arbitrary sequence, so there is much more control over where changes are made.
Yes, although it’s not completely arbitrary as you need a PAM sequence to be present right where you want to cut the DNA. It’s quite small though so chances are, you’ll find one in a convenient location