https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586825/
Frogs and other amphibians are actually incredibly sensitive to all manner of chemicals. Heavy metals, trace pharmaceutical contamination in human wastewater… They basically breathe water through their very thin skin and have delicate tissues overall. They provide unique issues for conservationists because they are usually the first water related species to collapse.
Humans have a history of being able to tolerate years and years of direct contact with arsenic, lead and various toxins. Your basic oil paint set from before 1950’s has a lifetimes worth of a modern person’s regular exposure. Frogs are a poor indicator of how humans react to anything.
Plant based estrogens don’t impact humans much. They do sheep… But only because they have four stomachs and can actually sort of process them. In humans they just slip through the system mostly untouched.
No prob! Science and frog conservation is cool.